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0883073807309786v1
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This version was published on May 1, 2008
Journal of Child Neurology, Vol. 23, No. 5, 543-549 (2008)
DOI: 10.1177/0883073807309786
© 2008 SAGE Publications

Rett Syndrome: Recent Research Progress

Alan K. Percy, MD

Departments of Pediatrics, Neurology, Neurobiology, and Genetics, University of Alabama at Birmingham, apercy{at}uab.edu

Recent progress in our understanding of Rett syndrome has been dramatic. Against the background that the clinical features of Rett syndrome may be reversible, in part or in whole, substantial optimism has emerged regarding possible therapies. As such, it is timely to update recent research progress. This update summarizes research advances during the past 18 to 24 months in terms of clinical and translational research, as well as basic research.

Key Words: Rett syndrome • research progress • MECP2 • mutations • mouse models


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