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Journal of Child Neurology
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Isolated Absence of the Moro Reflex in a Baby With CHARGE Syndrome Could Reflect Vestibular Abnormalities

Frank H. Bloomfield, FRACP, PhD

Newborn, Auckland City Hospital, Liggins Institute, University of Auckland, New Zealand, f.bloomfield{at}auckland.ac.nz

Shuan Dai, FRANZCO

Ophthalmology, Auckland City Hospital

David Perry, FRANZCR

Radiology, Auckland City Hospital

Salim Aftimos, MD

Genetic Services, Auckland City Hospital

We describe a term baby girl with (CHARGE syndrome coloboma, heart anomaly, choanal atresia, retardation, and genital and ear anomalies association) who had persistent complete absence of the Moro reflex but preservation of other primary neonatal reflexes. A computed tomography scan revealed bilateral absence of the semicircular canals and hypoplastic vestibules. We suggest that isolated absence of the Moro reflex may reflect underlying abnormalities of the vestibular system and may, therefore, not necessarily be associated with a generalized disturbance of the central nervous system as is usually the case. This suggestion has implications for the diagnostic and prognostic relevance of an isolated absent Moro reflex.

Key Words: neurodevelopment • primitive reflexes • congenital abnormality • CHARGE syndrome

Journal of Child Neurology, Vol. 23, No. 5, 561-563 (2008)
DOI: 10.1177/0883073807309779
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