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Journal of Child Neurology
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Increased Intracranial Pressure in a Case of Pediatric Multiple Sclerosis

Brice J. Williams, BS

Department of Neurosciences, Medical University of South Carolina

Holly J. Skinner, DO

Department of Neurosciences, Medical University of South Carolina

Bernard L. Maria, MD, MBA

Department of Neurosciences, Medical University of South Carolina, mariabl{at}musc.edu, Department of Pediatrics Charles P. Darby Children's Research Institute, Medical University of South Carolina, Charleston

A 15-year-old girl presented to our emergency department with dizziness, anorexia, nausea, and malaise. Clinical examination and magnetic resonance imaging studies showed characteristic features of multiple sclerosis. Surprisingly, a diagnostic lumbar puncture showed significant intracranial hypertension in addition to numerous oligoclonal bands, elevated immunoglobulin G index and immunoglobulin G/albumin ratio in the cerebrospinal fluid. It is proposed that a large burden of active demyelinating disease may cause increased intracranial pressure, thus providing an additional sound rationale for prompt therapeutic administration of intravenous high-dose steroids.

Key Words: pediatric multiple sclerosis • increased intracranial pressure

Journal of Child Neurology, Vol. 23, No. 6, 699-702 (2008)
DOI: 10.1177/0883073807313040
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