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1H-Magnetic Resonance Spectroscopy Markers of Cognitive and Language Ability in Clinical Subtypes of Autism Spectrum Disorders

Weinberg Child Development Center, Safra Children's Hospital, Tel Hashomer, affiliated with the Tel-Aviv University Sackler School of Medicine, Tel-Aviv, Israel, gabis{at}post.tau.ac.il

Wei Huang, PhD

Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York

Allen Azizian, PhD

Neuropsychiatric Institute and Hospital, University of California at Los Angeles, California

Carla DeVincent, PhD

Department of Pediatrics, State University of New York at Stony Brook

Alina Tudorica, PhD

Department of Radiology, State University of New York at Stony Brook

Yael Kesner-Baruch, MSc

Weinberg Child Development Center, Safra Children's Hospital, Tel Hashomer, affiliated with the Tel-Aviv University Sackler School of Medicine, Tel-Aviv, Israel

Patricia Roche, DO

Department of Radiology, State University of New York at Stony Brook

John Pomeroy, MBBS, MRCPsych

Department of Pediatrics, State University of New York at Stony Brook

This study assessed metabolic functioning of regional brain areas to address whether there is a neurometabolic profile reflecting the underlying neuropathology in individuals with autism spectrum disorders, and if varied profiles correlate with the clinical subtypes. Thirteen children (7-16 years) with autism spectrum disorders and 8 typically developing children were compared on ¹H-magnetic resonance spectroscopy data collected from hippocampus-amygdala and cerebellar regions. The autism spectrum disorder group had significantly lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions. Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder. Comparisons within the autism spectrum disorder group when clinically subdivided by history of speech delay revealed significant metabolic ratio differences. Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders.

Key Words: language • brain imaging • 1H-magnetic resonance spectroscopy • autism spectrum disorders

This version was published on July 1, 2008

Journal of Child Neurology, Vol. 23, No. 7, 766-774 (2008)
DOI: 10.1177/0883073808315423


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