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Neurological and Magnetic Resonance Imaging Findings in Children With Developmental Language Impairment

Departments of Neurology/Neurosurgery, McGill University Montreal, Child'en's Hospital Education Research Institute, Children's Hospital at Westmead, Westmead, NSW, Australia

Caroline Erdos, PhD

School of Communications Sciences and Disorders, McGill University Montreal

Karen Evans, MSc (SLP)

School of Communications Sciences and Disorders, McGill University Montreal

Annette Majnemer, PhD, OT

Department of Pediatrics, McGill University Montreal, School of Physical and Occupational Therapy, McGill University Montreal, Departments of Neurology/Neurosurgery, McGill University Montreal

Gaurav Saigal, MD, MBBS

Department of Radiology, McGill University Montreal

Eva Kehayia, PhD

School of Physical and Occupational Therapy, McGill University Montreal

Elin Thordardottir, PhD

School of Communications Sciences and Disorders, McGill University Montreal

Alan Evans, PhD

McConnell Brain Imaging Centre McGill University Montreal, Quebec, Canada

Michael I. Shevell, MD, CM, FRCPC

Departments of Neurology/Neurosurgery, McGill University Montreal, Department of Pediatrics, McGill University Montreal, michael.shevell{at}muhc.mcgill.ca

Neurologic and radiologic findings in children with well-defined developmental language impairment have rarely been systematically assessed. Children aged 7 to 13 years with developmental language impairment or normal language (controls) underwent language, nonverbal cognitive, motor and neurological assessments, standardized assessment for subtle neurological signs, and magnetic resonance imaging. Nine children with developmental language impairment and 12 controls participated. No focal abnormalities were identified on standard neurological examination. Age and developmental language impairment were independent predictors of neurological subtle signs scores (r² = 0.52). Imaging abnormalities were identified in two boys with developmental language impairment and no controls (P = .17). Lesions identified were predicted neither by history nor by neurological examination. Previously unsuspected lesions were identified in almost 25% of children with developmental language impairment. Constraints regarding cooperation and sedation requirements may limit the clinical application of imaging modalities in this population.

Key Words: language impairment • imaging

Journal of Child Neurology, Vol. 23, No. 8, 870-877 (2008)
DOI: 10.1177/0883073808315620


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