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Journal of Child Neurology
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Role of TNF-{alpha} Gene Variation in Idiopathic Childhood Ischemic Stroke: A Case-Control Study

Kai-Li Shi, MD

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing, China

Bing He, MD, PhD

Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

Jian-Jun Wang, MD

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing, China

Li-Ping Zou, MD, PhD

Department of Neurology, Beijing Children's Hospital, The Capital Medical University, Beijing, China, zouliping21{at}hotmail.com, Department of Pediatrics, Chinese PLA General Hospital, Beijing, China

Etiology of the idiopathic childhood stroke remains unknown. In previous studies, the immunologic process may be involved in the idiopathic stroke. Tumor necrosis factor— alpha (TNF-{alpha}), an important immune mediator, may contribute to the initiation and progression in the stroke. The main purpose of this study was to investigate correlation of TNF-{alpha} genetic variation and idiopathic childhood ischemic stroke. Using the direct DNA sequencing method, polymorphisms in the TNF-{alpha} promoter region were genotyped in 67 Chinese patients with idiopathic childhood stroke and 70 controls. Among totally 7 single nucleotide polymorphisms identified in the TNF-{alpha} promoter region, the variant of the -863C/A is associated with increased risk of idiopathic childhood ischemic stroke in our study group. TNF-{alpha} molecule may have genetically as well as functionally an important role in the pathogenesis of idiopathic childhood ischemic stroke in the Chinese population.

Key Words: childhood stroke • tumor necrosis factor-{alpha} • polymorphism

Journal of Child Neurology, Vol. 24, No. 1, 25-29 (2009)
DOI: 10.1177/0883073808321046
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