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Seizures are Common in the Acute Setting of Childhood Stroke: A Population-Based Study

Division of Child Neurology Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Pooja Khatri, MD

University of Cincinnati Academic Health Center, Department of Neurology and the Neuroscience Institute, Cincinnati, Ohio

Jane C. Khoury, PhD

Center for Epidemiology and Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

Kathleen Alwell, RN

University of Cincinnati Academic Health Center, Department of Neurology and the Neuroscience Institute, Cincinnati, Ohio

Jerzy P. Szaflarski, MD, PhD

University of Cincinnati Academic Health Center, Department of Neurology and the Neuroscience Institute, Cincinnati, Ohio

Joseph P. Broderick, MD

University of Cincinnati Academic Health Center, Department of Neurology and the Neuroscience Institute, Cincinnati, Ohio

Brett M. Kissela, MD

University of Cincinnati Academic Health Center, Department of Neurology and the Neuroscience Institute, Cincinnati, Ohio

Dawn O. Kleindorfer, MD

University of Cincinnati Academic Health Center, Department of Neurology and the Neuroscience Institute, Cincinnati, Ohio, kleinddo@ucmail.uc.edu

In our large population-based cohort, 3.1% of adults had seizures within the first 24 h of acute stroke. The objective of our study was to determine a similar incidence in children and compare by stroke subtype. Stroke cases in children between July 1993 to June 1994 and January 1999 to December 1999 were retrospectively identified and abstracted. We identified 31 strokes during the two study periods, including 17 ischemic strokes, 12 intracerebral hemorrhages, and 2 subarachnoid hemorrhages. Seizures occurred within 24 h of the stroke in 58% (18/31) of children. No significant differences were found in the rate of seizure by stroke subtype. The relative risk (95% confidence interval) for seizure in the acute stroke setting in children versus adults is 18 (13, 26). As compared with adults, seizures within the acute setting of childhood stroke are common with an occurrence rate in our population of 58%.

Key Words: seizures • cerebrovascular disease • stroke

This version was published on January 1, 2009

Journal of Child Neurology, Vol. 24, No. 1, 9-12 (2009)
DOI: 10.1177/0883073808320756


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