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Journal of Child Neurology
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Neuromuscular Hyperexcitability Associated with Acetylcholine Receptor Antibodies in a Child

Bjorn Oskarsson, MD

Department of Neurology, University of Colorado Denver, Colorado, bjorn.oskarsson{at}uchsc.edu

Lucyna Zawadzki, MD

Department of Pediatrics, Child Neurology Section University of Colorado Denver, Colorado

Timothy Benke, MD

Department of Pediatrics, Child Neurology Section University of Colorado Denver, Colorado

Dianna Quan, MD

Department of Neurology, Child Neurology Section University of Colorado Denver, Colorado

This report describes the clinical and electrophysiological features of an 8-year-old boy with autoimmune neuromuscular hyperexcitability. He presented with features of lower extremity pain, stiffness, and rippling muscles. The diagnosis was made by electromyography and supported by the presence of an antibody directed against nicotinic acetylcholine receptors. His symptoms responded to immunomodulatory treatment with intravenous immunoglobulin. Response to immunomodulatory therapy has not previously been described in the pediatric population with autoimmune neuromuscular hyperexcitability. This case highlights that this is a treatable condition.

Key Words: neuromuscular hyperexcitability • acetylcholine receptor antibody • neuromyotonia

This version was published on January 1, 2009

Journal of Child Neurology, Vol. 24, No. 1, 90-92 (2009)
DOI: 10.1177/0883073808320755
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