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Journal of Child Neurology
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What's this?

Pediatric High-Grade Gliomas and Diffuse Intrinsic Pontine Gliomas

Jason Fangusaro, MD

Department of Hematology/Oncology/Stem Cell Transplantation, Children's Memorial Hospital, Chicago, Illinois, jfangusaro{at}childrensmemorial.org

Pediatric high-grade gliomas represent approximately 10% of all pediatric brain tumors. Similar to adult high-grade gliomas, they behave very aggressively, and these children have a very poor prognosis despite a variety of therapies that include chemotherapy and radiotherapy. In this review, we present an overview of both pediatric high-grade gliomas and diffuse intrinsic pontine gliomas with a focus on their epidemiology, etiology, presentation, prognostic factors, biology, treatment modalities, outcomes, and future research directions.

Key Words: high-grade glioma • diffuse intrinsic pontine glioma • brainstem • glioblastoma

This version was published on November 1, 2009

Journal of Child Neurology, Vol. 24, No. 11, 1409-1417 (2009)
DOI: 10.1177/0883073809338960
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