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Journal of Child Neurology
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Neurologic Sequelae of Brain Tumors in Children

Nicole J. Ullrich, MD, PhD

Department of Neurology, Children's Hospital Boston, and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, nicole.ullrich{at}childrens.harvard.edu

Neurologic signs and symptoms are often the initial presenting features of a primary brain tumor and may also emerge during the course of therapy or as late effects of the tumor and its treatment. Variables that influence the development of such neurologic complications include the type, size, and location of the tumor, the patient’s age at diagnosis, and the treatment modalities used. Heightened surveillance and improved neuroimaging modalities have been instrumental in detecting and addressing such complications, which are often not appreciated until many years after completion of therapy. As current brain tumor therapies are continually refined and newer targeted therapies are developed, it will be important for future cooperative group studies to include systematic assessments to determine the incidence of neurologic complications and to provide a framework for the development of novel strategies for prevention and intervention.

Key Words: brain tumors • late effects • neurologic sequelae • chemotherapy • headache • hydrocephalus

Journal of Child Neurology, Vol. 24, No. 11, 1446-1454 (2009)
DOI: 10.1177/0883073809342491
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