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Journal of Child Neurology
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Late Effects of Therapy for Pediatric Brain Tumor Survivors

Christopher D. Turner, MD

Department of Pediatric Oncology, Dana Farber Cancer Institute and Children's Hospital Boston, Boston, Massachusetts, christopher_turner{at}dfci.harvard.edu

Celiane Rey-Casserly, PhD

Neuropsychology Program, Department of Psychiatry, Children's Hospital Boston, Boston, Massachusetts

Cori C. Liptak, PhD

Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, Massachusetts

Christine Chordas, RN, PNP

Department of Pediatric Oncology, Dana Farber Cancer Institute and Children's Hospital Boston, Boston, Massachusetts

Approximately 2 of every 3 of all pediatric patients with brain tumors will be long-term survivors. However, there is a steep cost for pediatric brain tumor survivors, and the group as a whole faces significantly more late effects than many other survivors of pediatric cancers. Most of these effects can be attributed to direct neurologic damage to the developing brain caused by the tumor and its removal, the long-term toxicity of chemotherapy, or the effects of irradiation on the central nervous system. The late effects experienced by childhood brain tumor survivors involve multiple domains. This article will review the significant late effects that occur within the medical, neurocognitive, psychosocial, and economic domains of the survivorship experience. We conclude by discussing how the late effects in different domains often coexist and can create a complex set of obstacles that pose significant challenges for a survivor of a pediatric brain tumor on a daily basis.

Key Words: late effects • brain tumors • survivorship • neurological deficits • neurocognitive deficits • psychosocial • quality of life • outcomes • transitions

Journal of Child Neurology, Vol. 24, No. 11, 1455-1463 (2009)
DOI: 10.1177/0883073809341709
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