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Ictal Vomiting as an Initial Symptom of Severe Myoclonic Epilepsy in Infancy: A Case Report

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan

Kazuhiro Haginoya, MD

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan, khaginoya{at}silk.ocn.ne.jp, Department of Pediatric Neurology, Takuto Rehabilitation Center for Children, Sendai

Noriko Togashi, MD

Eko-Ryouikuen, Hospital Home for Children and Persons with Severe Motor and Intellectual Disabilities, Sendai, Japan

Mitsugu Uematsu, MD

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan

Taro Kitamura, MD

Sendai City Hospital, Sendai

Yosuke Kakisaka, MD

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan

Mamiko Ishitobi, MD

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan

Keisuke Wakusawa, MD

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan

Kazuie Iinuma, MD

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan, Ishinomaki Red Cross Hospital, Ishinomaki

Hirokazu Oguni, MD

Department of Pediatrics, Tokyo Women's Medical University, Tokyo

Kazuhiro Yamakawa, PhD

Laboratory for Neurogenetics, Riken, Brain Science Institute, Saitama, Japan

Shigeru Tsuchiya, MD

Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan

We report on 3-year-old Japanese twin brothers suffering from ictal vomiting during infancy. Intractable seizures, including generalized tonic-clonic convulsions, and myoclonic seizures persisted in late infancy. The diagnosis of severe myoclonic epilepsy in infancy was confirmed by detecting a mutation in the voltage-gated sodium channel alpha subunit type gene. This is the first case report addressing ictal vomiting as the initial presentation of severe myoclonic epilepsy in infancy.

Key Words: ictal vomiting • severe myoclonic epilepsy • Panayiotopoulos syndrome • Rolandic epilepsy

Journal of Child Neurology, Vol. 24, No. 2, 228-230 (2009)
DOI: 10.1177/0883073808327839


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