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Journal of Child Neurology
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Receptive Language Organization in High-Functioning Autism

Richard E. Frye, MD, PhD

Department of Pediatrics, University of Texas Health Science Center at Houston, Houston, Texas, Richard.E.Frye{at}uth.tmc.edu

Michael S. Beauchamp, PhD

Department of Neuroscience, University of Texas Health Science Center at Houston, Houston, Texas

One of the core defining components of autism is impairment in communication, typically manifested as a delay in speech development. To date, neuroimaging studies have shed limited light on the mechanisms behind delay in speech development in autism. We performed magnetoencephalographic-based auditory language mapping in 2 cases of high-functioning autism. Overall, 2 distinct characteristics were found, such as the use of atypical language pathways and cortical hyperexcitability. These neurophysiological findings parallel those reported in 2 other developmental disorders, developmental dyslexia and Rett syndrome. We discuss common mechanisms that may account for cognitive delays across these developmental disorders.

Key Words: autism • language reorganization • magnetoencephalography

Journal of Child Neurology, Vol. 24, No. 2, 231-236 (2009)
DOI: 10.1177/0883073808329572


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