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Diffusion-Weighted Imaging Findings in Hemolytic Uremic Syndrome With Central Nervous System Involvement

Department of Pediatrics, University of Padua, Padova, Italy, irene.toldo{at}unipd.it

Renzo Manara, MD

Institute of Neuroradiology, Padua Hospital, Padua, Italy

Paola Cogo, MD, PhD

Department of Pediatrics, University of Padua, Padova, Italy

Stefano Sartori, MD

Department of Pediatrics, University of Padua, Padova, Italy

Luisa Murer, MD

Department of Pediatrics, University of Padua, Padova, Italy

Pier Antonio Battistella, MD

Department of Pediatrics, University of Padua, Padova, Italy

Anna Maria Laverda, MD

Department of Pediatrics, University of Padua, Padova, Italy

Hemolytic uremic syndrome is a multisystem disease that can affect central nervous system in up to 50% of cases. Central nervous system involvement can be clinically severe and its pathogenesis is not yet fully understood. Various magnetic resonance imaging findings, on conventional sequences, documenting the involvement of deep gray-matter structures, have been described. Diffusion-weighted imaging features of brain lesions have been reported only in 2 cases, but the potential role of this technique has not been considered yet. We describe a 19-month-old child affected by hemolytic uremic syndrome with basal ganglia lesions documented by diffusion-weighted imaging, with a 42-day neuroradiological follow-up and a 6-month clinical follow-up. In our case, diffusion-weighted imaging was more sensible in detecting the affected brain areas compared to T1, suggesting that reduced apparent diffusion coefficient values in the acute phase could reliably identify irreversible brain lesions in hemolytic uremic syndrome patients.

Key Words: hemolytic uremic syndrome • basal ganglia

This version was published on February 1, 2009

Journal of Child Neurology, Vol. 24, No. 2, 247-250 (2009)
DOI: 10.1177/0883073808323022


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