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Journal of Child Neurology
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0883073808324535v1
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*Compound via MeSH
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*CARBAMAZEPINE
*FRUCTOSE
Medline Plus Health Information
*Seizures
*Tuberous Sclerosis
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What's this?

Rapamycin Reduces Seizure Frequency in Tuberous Sclerosis Complex

Jennifer Muncy, BA

The University of Texas Health Science Center Houston, Texas

Ian J. Butler, MB, BS, FRACP

Department of Pediatrics, Division of Child and Adolescent Neurology

Mary Kay Koenig, MD

Department of Pediatrics, Division of Child and Adolescent Neurology, mary.k.koenig{at}uth.tmc.edu

The authors present a 10-year-old girl with tuberous sclerosis complex who has been receiving rapamycin for 10 months for seizure control. She was started at 0.05 mg/kg/d and titrated to an effective dose of 0.15 mg/kg/d. There was a dramatic reduction in seizure frequency with rapamycin therapy. Further studies are needed to objectively investigate the benefits of rapamycin in tuberous sclerosis complex and to clarify its mechanism of seizure control.

Key Words: tuberous sclerosis • rapamycin • seizures

This version was published on April 1, 2009

Journal of Child Neurology, Vol. 24, No. 4, 477 (2009)
DOI: 10.1177/0883073808324535
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