Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kahle, K. T.
Right arrow Articles by Staley, K. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kahle, K. T.
Right arrow Articles by Staley, K. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Decreased Seizure Activity in a Human Neonate Treated With Bumetanide, an Inhibitor of the Na+-K+-2Cl- Cotransporter NKCC1

Kristopher T. Kahle, MD, PhD

Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts

Sarah M. Barnett, MD, MPH

Department of Neurology, Division of Pediatric Neurology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts

Kenneth C. Sassower, MD

Department of Neurology, Division of Pediatric Neurology Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts

Kevin J. Staley, MD

Department of Neurology, Division of Pediatric Neurology Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, kstaley{at}partners.org

Neonatal seizures have devastating consequences for brain development and are inadequately treated by available antiepileptics. In neonates, g-aminobutyric acid (GABA) is an excitatory neurotransmitter due to elevated levels of intraneuronal chloride achieved by robust activity of the Na+-K+-2Cl - cotransporter (NKCC1). This depolarizing action of GABA likely contributes to the lowered seizure threshold, increased seizure propensity, and poor efficacy of GABAergic anticonvulsants among infants. The diuretic bumetanide inhibits NKCC1 and silences seizure activity in rodent models of neonatal seizures, but its effect on seizures in human neonates is unknown. Continuous electroencephalography (EEG) monitoring was used to quantify the number, duration, and frequency of seizures 2 hours before and after the administration of bumetanide in a neonate with intractable multifocal seizures. Significant reductions in mean seizure duration and frequency were noted following treatment, with no associated clinical side effects or metabolic imbalances. These results suggest bumetanide may exert antiepileptic effects in human neonates.

Key Words: neonatal seizures • bumetanide • Na+-K+-2Cl- cotransporter NKCC1

Journal of Child Neurology, Vol. 24, No. 5, 572-576 (2009)
DOI: 10.1177/0883073809333526
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 PhysiologyHome page
K. T. Kahle, J. M. Simard, K. J. Staley, B. V. Nahed, P. S. Jones, and D. Sun
Molecular Mechanisms of Ischemic Cerebral Edema: Role of Electroneutral Ion Transport
Physiology, August 1, 2009; 24(4): 257 - 265.
[Abstract] [Full Text] [PDF]