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Journal of Child Neurology
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0883073808327835v1
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Recurrent Stroke in a Child With Incontinentia Pigmenti

Michael S. Cartwright, MD

Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, mcartwri{at}wfubmc.edu

David L. White, BS

Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

Lewis M. Miller, III, MD

Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

E. Steve Roach, MD

Section of Child Neurology, The Ohio State University College of Medicine, Columbus, Ohio

We report a child with genetically proven incontinentia pigmenti who had bilateral strokes at 5 days of age, and was subsequently found to have recurrent acute strokes on magnetic resonance imaging both at 10 days and 3 months of age. Brain magnetic resonance imaging at 5 days of age showed multiple areas of restricted diffusion throughout both hemispheres. The child was started on antiplatelet therapy after a second stroke was noted on magnetic resonance imaging at 10 days of age. Despite this treatment, she had a third punctate infarct on magnetic resonance imaging 3 months later. A magnetic resonance imaging at 10 months of age showed maturation of the old infarcts but no new strokes. The purpose of this article is to describe a unique presentation of recurrent stroke secondary to incontinentia pigmenti and to highlight the need for a better understanding of the pathophysiology of incontinentia pigmenti to develop appropriate treatment of stroke in incontinentia pigmenti.

Key Words: incontinentia pigmenti • stroke • neurocutaneous syndrome

This version was published on May 1, 2009

Journal of Child Neurology, Vol. 24, No. 5, 603-605 (2009)
DOI: 10.1177/0883073808327835
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