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Association of Campylobacter jejuni Infection with Childhood Guillain-Barré Syndrome: A Case-Control Study

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India, kalra.veena{at}gmail.com

Rama Chaudhry, MD

Department of Microbiology, All India Institute of Medical Sciences, New Delhi 110029, India

Tarun Dua, MD

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India

Benu Dhawan, MD

Department of Microbiology All India Institute of Medical Sciences, New Delhi 110029, India

Jitendra K. Sahu, MD

Department of Pediatrics, All India Institute of Medical Sciences, New Delhi 110029, India

B. Mridula, MSc

Department of Microbiology All India Institute of Medical Sciences, New Delhi 110029, India

A prospective case-control study was conducted to determine the association between Campylobacter jejuni infection and childhood Guillain-Barré syndrome in the Indian population. We found evidence of recent Campylobacter jejuni infection in 27.7% of patients with Guillain-Barré syndrome, as compared with 2.3% in neurological controls (P = .003) and 2.3% in nonneurological controls (P = .003). Of the 15 patients with Campylobacter jejuni infection, 8 (53.3%) reported having had diarrhea within 12 weeks before the onset of the neurologic illness. Our results suggest association between recent Campylobacter jejuni infection and bulbar weakness (P = .043). No statistical difference was observed between the Campylobacter jejuni positive and negative groups with respect to age, other clinical features, albuminocytological dissociation, and residual paralysis at follow-up. It is concluded that subclinical Campylobacter jejuni infection is an important antecedent illness in childhood Guillain-Barré syndrome in the Indian population.

Key Words: Campylobacter jejuni • Guillain-Barré syndrome • Indian population

Journal of Child Neurology, Vol. 24, No. 6, 664-668 (2009)
DOI: 10.1177/0883073808325649


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