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Journal of Child Neurology
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Benign Lesions Accompanied by Intractable Epilepsy in Children

George A. Alexiou, MD, PhD

Department of Neurosurgery, Children's Hospital "Agia Sofia," Athens, Greece, alexiougrg{at}yahoo.gr

Maria Varela, MD

Department of Neurosurgery, Children's Hospital "Agia Sofia," Athens, Greece

George Sfakianos, MD, PhD

Department of Neurosurgery, Children's Hospital "Agia Sofia," Athens, Greece

Neofytos Prodromou, MD, PhD

Department of Neurosurgery, Children's Hospital "Agia Sofia," Athens, Greece

Epilepsy surgery has been proposed as a safe alternative treatment for intractable epilepsy in children, especially for patients with structural brain abnormalities. We studied 24 consecutive children who underwent surgery for intractable epilepsy. There were 12 males and 12 females. The mean age was 6.5 years. The seizures' duration ranged from 6 months to 2 years. The histopathological examination of the resected lesions revealed in 12 cases the presence of a ganglioglioma, in 7 cases dysembryoplastic neuroepithelial tumor, in 1 case a low grade glioma, in 2 cases cortical dysplasia, and in 2 cases cavernous malformations. In 18 cases, the lesions were located in the temporal lobe and in 6 cases the lesions were extratemporal. After a mean follow-up period of 4.4 years, 79% (19/24) of patients were seizure free. There were no permanent neurological deficits or deaths. Surgery for focal epilepsy in children is a safe procedure with favorable results.

Key Words: focal epilepsy • epilepsy surgery • cortical dysplasia • neoplasm

This version was published on June 1, 2009

Journal of Child Neurology, Vol. 24, No. 6, 697-700 (2009)
DOI: 10.1177/0883073808331079
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