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Angiocentric Glioma—Induced Seizures in a 2-Year-Old Child

Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center

Dave F. Clarke, MD

Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, dclarke3{at}utmem.edu, Le Bonheur Comprehensive Epilepsy Program, LeBonheur Children's Medical Center

James W. Wheless, MD

Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, Le Bonheur Comprehensive Epilepsy Program, LeBonheur Children's Medical Center

David W. Ellison, MD

Departments of Radiology and Pathology, St Jude Children's Research Hospital Memphis, Tennessee

Robert Ogg, MD

Departments of Radiology and Pathology, St Jude Children's Research Hospital Memphis, Tennessee

Frederick A. Boop, MD

Department of Pediatrics, Division of Pediatric Neurology, University of Tennessee Health Science Center, Le Bonheur Comprehensive Epilepsy Program, LeBonheur Children's Medical Center

A 2-year-old child presented with medically refractory seizures and was found to have a right frontoparietal parasagittal angiocentric glioma. Depth electrodes were used to document ictal onset from within the tumor rather than from the surrounding tissues. Ictal activity then spread to a wide area on the cortical surface, including the region around the tumor and hand motor cortex. Lesionectomy permitted sparing of adjacent areas of eloquent cortex, and the child is now seizure-free on monotherapy.

Key Words: angiocentric glioma • symptomatic partial epilepsy • functional mapping • epilepsy surgery • brain tumor

This version was published on July 1, 2009

Journal of Child Neurology, Vol. 24, No. 7, 852-856 (2009)
DOI: 10.1177/0883073808331078


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