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Acute Disseminated Encephalomyelitis with Bilateral Thalamic Necrosis

Department of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece

Persa Kountra, MD

Department of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece

Eftychia Kapsalaki, MD, PhD

Department of Radiology, University Hospital of Larissa, University of Thessaly, Larissa, Greece

Georgia Protogerou, MD

Department of Radiology University Hospital of Larissa, University of Thessaly, Larissa, Greece

Katerina Markopoulou, MD, PhD

Department of Neurology, University Hospital of Larissa, University of Thessaly, Larissa, Greece, emarkopo{at}med.uth.gr

Acute disseminated encephalomyelitis is a monophasic inflammatory demyelinating disease of the central nervous system involving the white matter, and to a lesser extent, the gray matter. Bilateral thalamic lesions have been reported in 12% of pediatric patients with acute disseminated encephalomyelitis. In most cases, there is a benign clinical course and complete resolution of the lesions. Here, we describe a case in which acute disseminated encephalomyelitis is associated with severe neurological deficits and bilateral thalamic necrosis. Necrosis should be considered in cases of acute disseminated encephalomyelitis with persistent severe neurological deficits. Its presence is a poor prognostic indicator.

Key Words: acute disseminated encephalomyelitis • thalamic necrosis • β-thalassemia

This version was published on August 1, 2009

Journal of Child Neurology, Vol. 24, No. 8, 1001-1004 (2009)
DOI: 10.1177/0883073808331364


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