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Journal of Child Neurology
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Positron Emission Tomography Imaging of Neuroinflammation

Sujatha Kannan, MD

Carman and Ann Adams Department of Pediatrics Wayne State University School of Medicine, Detroit, Michigan, skannan{at}med.wayne.edu

Bindu Balakrishnan, PhD

Carman and Ann Adams Department of Pediatrics Wayne State University School of Medicine, Detroit, Michigan

Otto Muzik, PhD

Carman and Ann Adams Department of Pediatrics Wayne State University School of Medicine, Detroit, Michigan, Department of Radiology Wayne State University School of Medicine, Detroit, Michigan

Roberto Romero, MD

Perinatology Research Branch, National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Department of Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan

Diane Chugani, PhD

Department of Radiology Wayne State University School of Medicine, Detroit, Michigan, Carman and Ann Adams Department of Pediatrics Wayne State University School of Medicine, Detroit, Michigan

Injury to the central nervous system is characterized by localization of activated microglia at the site of injury. The peripheral benzodiazepine receptor expressed on the outer mitochondrial membrane of the activated microglia is a sensitive biomarker for the detection of this neuroinflammatory response to an insult. PK11195, an isoquinoline ligand that specifically binds peripheral benzodiazepine receptor, can be tagged with a positron emitter and used as a tracer for molecular imaging of this receptor in vivo by positron emission tomography (PET). [11C](R)PK11195 has been used in the imaging of various neuroinflammatory disorders, such as Alzheimer disease and multiple sclerosis. On the basis of our small-animal PET imaging studies using a neonatal rabbit model of maternal inflammation-induced cerebral palsy, we propose that PET imaging using [11C](R)PK11195 may be a valuable tool for detecting neuroinflammation in the brain of newborns born to mothers with chorioamnionitis.

Key Words: PET • neuroinflammation

Journal of Child Neurology, Vol. 24, No. 9, 1190-1199 (2009)
DOI: 10.1177/0883073809338063
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