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Psychologic and Neurologic Function Following Treatment for Childhood Temporal Lobe Astrocytoma

Department of Pediatrics, Medical College of Wisconsin and Milwaukee Children's Hospital, Midwest Children's Cancer Center Milwaukee, WI

Edward H. Kovnar, MD

Department of Neurology, Medical College of Wisconsin and Milwaukee Children's Hospital

Larry E. Kun, MD

Department of Radiation Oncology Medical College of Wisconsin and Milwaukee Children's Hospital, Midwest Children's Cancer Center Milwaukee, WI

J. Jeffrey Crisco, PhD

Department of Pediatrics, Medical College of Wisconsin and Milwaukee Children's Hospital

J. Michael Williams, PhD

Department of Psychology, Memphis State University, Memphis, TN

Seven school-aged children treated for temporal lobe astrocytomas with surgical resection and irradiation were prospectively tested to evaluate their intellectual, academic, personality, and neurologic status after therapy. At their most recent follow-up examination, neuropsychologic functioning was adequate in only two patients. The other five children manifested either intellectual deterioration, learning disability, mental retardation, or psychopathology. These deficits were associated with poor postoperative performance status, inadequate seizure control, tumor recurrence, and younger age at diagnosis. No pattern of intellectual, academic, or personality dysfunction emerged in association with left- versus right-hemisphere tumors. (J Child Neurol 1988;3:47-52).

Journal of Child Neurology, Vol. 3, No. 1, 47-52 (1988)
DOI: 10.1177/088307388800300111


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