This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Scher, M. S. Search for Related Content PubMed PubMed Citation Articles by Scher, M. S. Social Bookmarking                         What's this?

Midline Electrographic Abnormalities and Cerebral Lesions in the Newborn Brain

University of Pittsburgh and the Department of Pediatrics, Magee-Women's Hospital, Pittsburgh, PA

Electroencephalographic (EEG) abnormalities arising from the midline region were identified in 154 of 1008 (15.2%) consecutive neonatal EEGs during a 24-month period. These records were obtained on 97 neonates with a variety of clinical diagnoses. Premature infants made up 79% (77/97) of this group. All patients received at least one cranial ultrasound at 7 to 10 days of life. Sixty-two percent (60/97) of the patients had radiographic and/or neuropathological documentation of cerebral lesions: intraventricular hemorrhage (25), periventricular leukomalacia (18), cerebral infarction (10), cerebral malformation (4), and miscellaneous lesions (3). Six types of midline EEG abnormalities are described: negative sharp waves, positive sharp waves, electrographic discharges associated with myoclonus, electrographic seizures, attenuation of background, and rhythmic monofrequencies. Approximately 90% of the patients with background attenuation, discharges with myoclonus, and positive sharp waves and 72% of patients with EEG seizures had cerebral lesions. Midline positive sharp waves were associated with periventricular leukomalacia as well as intraventricular hemorrhage. No midline positive sharp waves, attenuation, EEG seizures or discharges with myoclonus were found in 25 healthy, asymptomatic neonates. Besides positive sharp waves, other specific midline EEG abnormalities can be associated with cerebral lesions in the neonate. The rapid identification of midline EEG abnormalities in neonatal recordings can enhance the accuracy of both electrographic diagnosis and anatomic localization of associated cerebral lesions. (J Child Neurol 1988;3:135-146).

Journal of Child Neurology, Vol. 3, No. 2, 135-146 (1988)
DOI: 10.1177/088307388800300212


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				T. E. Inder, L. Buckland, C. E. Williams, C. Spencer, M. I. Gunning, B. A. Darlow, J. J. Volpe, and P. D. Gluckman Lowered Electroencephalographic Spectral Edge Frequency Predicts the Presence of Cerebral White Matter Injury in Premature Infants Pediatrics, January 1, 2003; 111(1): 27 - 33. [Abstract] [Full Text] [PDF]

				M. S. Scher and M. Beggarly Clinical Significance of Focal Periodic Discharges in Neonates J Child Neurol, July 1, 1989; 4(3): 175 - 185. [Abstract] [PDF]