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Journal of Child Neurology
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Rett Syndrome: Review and Discussion of Current Diagnostic Criteria

Larry Burd, MS

Child Evaluation and Treatment Program, Medical Center Rehabilitation Hospital, and the Departments of Neurology and Pediatrics and the Center for Teaching and Learning, University of North Dakota, Grand Forks, ND, Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia

Generoso G. Gascon, MD

Child Evaluation and Treatment Program, Medical Center Rehabilitation Hospital, and the Departments of Neurology and Pediatrics and the Center for Teaching and Learning, University of North Dakota, Grand Forks, ND, Department of Pediatrics, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia

Rett syndrome is a mental retardation syndrome that occurs only in females and consists of normal pre-, peri-, and neonatal growth and development. It is followed by rapid neurobehavioral deterioration in late infancy or early childhood, a developmental arrest, plateauing, and then either a course of retarded development or continued deterioration. The period of rapid neuro-behavioral deterioration manifests as a partial autistic syndrome, with loss of production and comprehension of language, hyperactivity, hyperventilation, hand-wringing, and ataxic gait. Current diagnostic criteria are discussed and suggestions for further research are presented. (J Child Neurol 1988;3:263-268).

Journal of Child Neurology, Vol. 3, No. 4, 263-268 (1988)
DOI: 10.1177/088307388800300406
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