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Journal of Child Neurology
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Intraventricular Interferon Treatment for Subacute Sclerosing Panencephalitis

I. Steiner, MD

Department of Neurology, Hadssah University Hospital and Hebrew University-Hadassah Medical School

I. Wirguin, MD

Department of Neurology, Hadssah University Hospital and Hebrew University-Hadassah Medical School

A. Morag, MD

Division of Clinical Virology, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel

O. Abramsky, MD, PhD

Department of Neurology, Hadssah University Hospital and Hebrew University-Hadassah Medical School

Paul R. Dyken, MD

Department of Neurology, Hadssah University Hospital and Hebrew University-Hadassah Medical School

Three children with subacute sclerosing panencephalitis (SSPE) were treated with alpha-interferon. Medication was administered via an Ommaya reservoir into the cerebral ventricular system over a period of 13 to 24 months in increasing amounts up to 1.0 X 106 IU twice weekly. Mild clinical improvement in two children and a stable course in the third were associated with improvement of electroencephalographic recordings in all patients and a decrease in antimeasles antibodies in the cerebrospinal fluid of two. The small number of patients does not enable us to determine whether this course was the natural history of SSPE in our patients or whether it was induced by treatment, yet it seems that intraventricular interferon treatment can modify the course of SSPE. ( J Child Neurol 1989;4:20-23).

Journal of Child Neurology, Vol. 4, No. 1, 20-24 (1989)
DOI: 10.1177/088307388900400103
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