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Journal of Child Neurology
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Neonatal Form of Nemaline Myopathy, Muscle Immaturity, and a Microvascular Injury

Anna Fidzianska, MD

Department of Neurology, Medical Academy, Warsaw, Poland

Hans H. Goebel, MD

Division of Neuropathology, University of Mainz, Mainz

Marion Kleine, MD

Märkische Kinderklinik Hamm, FRG

An infant with a neonatal form of nemaline myopathy showed ultrastructural features of muscle immaturity. Immaturity was characterized by an abnormal presence of myotubes, as well as cells in clusters within a common basement membrane and a great number of satellite cells adhering to very small muscle fibers. In addition, degenerative changes and a severe microvascular lesion were observed. The pathologic findings in the muscle of this patient were those of neonatal nemaline myopathy complicating severe microvascular injury, possibly induced by an unknown toxic agent. ( J Child Neurol 1990;5:122-126).

Journal of Child Neurology, Vol. 5, No. 2, 122-126 (1990)
DOI: 10.1177/088307389000500209
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