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Neuroimaging Findings in Alexander's Disease

Division of Pediatric Neurology, Department of Neurology

Adolfo Garnica, MD

Division of Genetics, Endocrine, and Metabolism, Department of Pediatrics

G. Bradley Schaefer, MD

Division of Genetics, Endocrine, and Metabolism, Department of Pediatrics

Joe C. Leonard, MD

Division of Nuclear Medicine, Department of Radiology

Don Wilson, MD

Division of Magnetic Resonance Imaging, Department of Radiology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

Warren A. Marks, MD

Fort Worth Child Neurology Associates, Ft Worth, TX

Richard W. Leech, MD

Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

Roger A. Brumback, MD

Department of Pathology, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK

We present the findings from magnetic resonance imaging, computed tomographic scan, and single photon emission computed tomography of the brain in a 2-year-old girl with Alexander's disease. Computed tomographic scans showed prominent low-density white matter throughout the cerebral hemispheres. Magnetic resonance imaging showed increased T₂ signal from the cerebral white matter but not the cerebellum or brain stem. Single photon emission computed tomography revealed diminished cerebral metabolism, particularly in the frontal regions, as compared with the cerebellum. (J Child Neurol 1990;5:253-258).

Journal of Child Neurology, Vol. 5, No. 3, 253-258 (1990)
DOI: 10.1177/088307389000500321


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