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Journal of Child Neurology
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Hypoplastic Corpus Callosum in Ocular Albinism: Indication of a Global Disturbance of Neuronal Migration

John B. Bodensteiner, MD

Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, Department of Pediatrics West Virginia University School of Medicine, Morgantown, WV

Lenore Breen, MD

Department of Neurology, West Virginia University School of Medicine, Morgantown, WV, Department of Ophthalmology, West Virginia University School of Medicine, Morgantown, WV

Terry L. Schwartz, MD

Department of Ophthalmology, West Virginia University School of Medicine, Morgantown, WV

G. Bradley Schaefer, MD

Department of Pediatrics Oklahoma University College of Medicine, Oklahoma City, OK

Ocular albinism is distinguished from the more common oculocutaneous albinism by the presence of normal pigmentation of skin and hair in the former condition. Recent studies of ocular albinism have shown that the hypopigmentation of the optic fundus is associated with a number of anomalies of neuronal wiring involving the visual system. We present a patient with ocular albinism who also has a hypoplastic corpus callosum as determined by analysis of midsagittal magnetic resonance imaging scans. Previous studies of the hypoplastic corpus callosum indicate that this anomaly is a defect in neuronal migration as well. The finding of a hypoplastic corpus callosum in a patient with ocular albinism suggests a more generalized defect in neuronal migration not limited to the visual system. (J Child Neurol 1990;5:341-343).

Journal of Child Neurology, Vol. 5, No. 4, 341-343 (1990)
DOI: 10.1177/088307389000500415
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