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Age-Related Changes in the Relative Growth of the Posterior Fossa

Department of Pediatrics, University of Oklahoma Health Sciences

James N. Thompson, Jr, PhD

Department of Zoology, Oklahoma University, Norman, OK

John B. Bodensteiner, MD

Department of Neurology, West Virginia University College of Medicine, Morgantown, WV

Monique Gingold

Department of Neurology, West Virginia University College of Medicine, Morgantown, WV

Melissa Wilson

Department of Radiology, University of Oklahoma Health Sciences Center, Oklahoma City

Don Wilson, MD

Department of Zoology, Oklahoma University, Norman, OK

We have established a normative data set for the relative size of the structures of the midline posterior fossa from birth to 90 years old. Data were obtained from morphometric analysis of midsagittal magnetic resonance imaging scans of the brain utilizing a simple image analysis system. There are several significant changes in the size of these structures with an increase in chronologic age. The relative size of the cisterna magna decreases with age. Anterior cerebellar vermal lobules (I through V) appear to grow more rapidly than the rest of the cerebellum. Other, less significant, trends include a decrease in the overall size of the cerebellum, superior posterior vermal lobules (VI and VII) and inferior posterior lobule (VIII) with an increase in age. It is, therefore, necessary to use age-standardized normative data when making morphometric correlations with clinical disorders. (J Child Neurol 1991;6:15-19).

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