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Sleep-Disordered Breathing in Möbius Syndrome

Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, Department of Pediatrics College of Medicine, University of Kentucky, Lexington, KY

Peggy Falace, MD

Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY

Jamshed Kanga, MD

Department of Pediatrics College of Medicine, University of Kentucky, Lexington, KY

Robert Baumann, MD

Department of Neurology, College of Medicine, University of Kentucky, Lexington, KY, Department of Pediatrics, College of Medicine, University of Kentucky, Lexington, KY

Möbius syndrome is a complex neurologic disorder characterized by congenital bilateral facial paralysis associated with lateral gaze paralysis. The syndrome has variable manifestations and several variants, some with somatic stigmata. In 1990, Möbius syndrome is conceptualized as a spectrum of clinical caudal brain-stem signs. Some deficits are manifested by laryngeal paralysis and aspiration. Sleep-disordered breathing syndromes have not been previously reported in association with Möbius syndrome. We report two children with Möbius syndrome and sleep-disordered breathing. Based on known pathologic findings and clinical manifestations, we believe that sleep-disordered breathing may be a common complication of Möbius syndrome and should be sought, since potential outcomes of such complications include serious morbidity. (J Child Neurol 1991;6:73-77).

Journal of Child Neurology, Vol. 6, No. 1, 73-77 (1991)
DOI: 10.1177/088307389100600115


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