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Journal of Child Neurology
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*Attention Deficit Hyperactivity Disorder
Hazardous Substances DB
*METHYLPHENIDATE
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The Go-No Go Test in Attention Deficit Disorder Is Sensitive to Methylphenidate

Barbara L. Trommer, MD

Department of Pediatrics, Division of Neurology, Evanston Hospital, 2650 Ridge Avenue, Evanston, IL

Jo-Ann B. Hoeppner, PhD

the Evaluation Center for Learning, Northwestern University Medical School, Evanston Hospital, Evanston, IL

Steven G. Zecker, PhD

Program in Learning Disabilities, Northwestern University School of Speech, Evanston, IL

The go-no go test requires a subject to emit a simple motor response to one cue while inhibiting the response in the presence of another cue. This test has been effective in demonstrating impulsivity (elevated commission error rate) in children with attention deficit disorder (ADD). In this study, we examined the effects on go-no go test performance of two doses of methylphenidate (0.15 mg/kg and 0.3 mg/kg) administered in double-blind placebo-controlled fashion to children with ADD. Our results indicate that even modest doses of methylphenidate improve the go-no go performance of these children by decreasing their tendency to make impulsive commission errors. Thus the test is sensitive to the effects of methylphenidate and can be used to monitor a response to therapy. (J Child Neurol 1991; 6(Suppl):S126-S129).

Journal of Child Neurology, Vol. 6, No. 1 suppl, S128-S131 (1991)
DOI: 10.1177/0883073891006001131
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