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Cerebrospinal Fluid β-Endorphin and Cortisol Study in Rett Syndrome

From the Unité de Neuropédiatrie

Nicole Bressot, MD

MIB, Centre Gui de Chauliac, and the Laboratoire de Médecine Nucléaire

Mata Bassir, MD

From the Unité de Neuropédiatrie

Jean-Pierre Daures, MD

Service d'Informatique Médicale et de Biostatistique, Hôpital Lapeyronie, Montpellier, France

Antoine Rabinowitz, MD

Unité de Neuropédiatrie

An evaluation of cerebrospinal fluid and plasma β-endorphin and cortisol levels was performed in 15 girls affected with classic Rett syndrome. There were no differences between the patient group and the control group in plasma cortisol and β-endorphin levels. But in Rett syndrome, a significant increase in β-endorphin was noted in the cerebrospinal fluid, with an elevation of the cerebrospinal fluid/plasma β-endorphin ratio and a decrease in cerebrospinal fluid cortisol. A substantial overlap between patients and control group diminishes the diagnostic value of cerebrospinal fluid β-endorphin assay in girls suspected of having Rett syndrome. (J Child Neurol 1991;6:257-262).

Journal of Child Neurology, Vol. 6, No. 3, 257-262 (1991)
DOI: 10.1177/088307389100600310


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