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Journal of Child Neurology
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Effects of Benzoylecgonine on the Behavior of Suckling Rats: A Preliminary Report

Richard J. Konkol, MD, PhD

Department of Neurology, The Medical College of Wisconsin, Children's Hospital of Wisconsin

Julie K. Doerr, BS

Department of Neurology, The Medical College of Wisconsin

Jane A. Madden, PhD

Department of Neurology, The Medical College of Wisconsin, Research Service Zablocki VA Medical Center, Milwaukee, WI

A major metabolite of cocaine, benzoylecgonine, causes behavioral activation that progresses to seizures when given intraventricularly to 2-week-old rats. The seizures are characterized by running, hopping, and vocalizing and are mixed with shorter-duration tonic episodes. Pretreatment with haloperidol, at a dose aimed at blocking stereotyped behavior, did not suppress these behaviors. In contrast, seizures were prevented by antiepileptic drugs, with the order of potency being diazepam > phenobarbital > phenytoin. We hypothesize that the long-lasting cocaine metabolite, benzoylecgonine, contributes to the infant cocaine intoxication syndrome. (J Child Neurol 1992;7:87-92).

Journal of Child Neurology, Vol. 7, No. 1, 87-92 (1992)
DOI: 10.1177/088307389200700115
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R. J. Konkol, L. J. Murphey, D. M. Ferriero, D. A. Dempsey, and G. D. Olsen
Cocaine Metabolites in the Neonate: Potential for Toxicity
J Child Neurol, July 1, 1994; 9(3): 242 - 248.
[Abstract] [PDF]