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Journal of Child Neurology
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Topical Review Article: Medulloblastoma: I. Clinical, Diagnostic, and Therapeutic Overview

Frank H. Tomlinson, MBBS, FRACS, PhD

Department of Neurosurgery

Bernd W. Scheithauer, MD

Department of Laboratory Medicine and Pathology

Fredric B. Meyer, MD

Department of Neurosurgery

William A. Smithson, MD

Department of Pediatric Oncology

Edward G. Shaw, MD

Department of Radiotherapy

Gary M. Miller, MD

Department of Diagnostic Radiology

Robert V. Groover, MD

Department of Pediatric Neurology, Mayo Clinic, Rochester, MN

Medulloblastoma, the most common embryonal tumor of the central nervous system, affects both children and adults. It poses a significant therapeutic challenge in that age-dependent differences exist, not only in their pathobiology, but in the efficacy of chemotherapy and radiotherapy. This is particularly the case in very young children, whose still developing nervous system exhibits a low tolerance to radiotherapy. We review the epidemiology, clinical presentation, radiologic features, and current therapeutic concepts relative to this unique neoplasm. Efforts are made to highlight clinical controversies. (J Child Neurol 1992;7:142-155).

Journal of Child Neurology, Vol. 7, No. 2, 142-155 (1992)
DOI: 10.1177/088307389200700203
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