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Journal of Child Neurology
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Increased Intracranial Pressure in Alexander Disease: A Rare Presentation of White-Matter Disease

Leonardo Garcia, MD

King Fahd National Guard Hospital and King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Generoso Gascon, MD

King Fahd National Guard Hospital and King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Pinar Ozand, MD

King Fahd National Guard Hospital and King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

Hassan Yaish, MD

King Fahd National Guard Hospital and King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

A patient with biopsy-proven Alexander disease presented with progressive head enlargement and clinical evidence of increased intracranial pressure. Lumbar puncture under sedation confirmed increased intracranial pressure with otherwise normal cerebrospinal fluid values. The association of megalencephaly, increased intracranial pressure and neuroimaging evidence of leukoencephalopathy should alert pediatric neurologists to the possibility of Alexander disease. (J Child Neurol 1992;7:168-171).

Journal of Child Neurology, Vol. 7, No. 2, 168-171 (1992)
DOI: 10.1177/088307389200700206
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