This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Hashimoto, T. Articles by Kuroda, Y. Search for Related Content PubMed PubMed Citation Articles by Hashimoto, T. Articles by Kuroda, Y. Social Bookmarking                         What's this?

Circadian Rhythm in Patients With Hydranencephaly

Department of Pediatrics, University of Tokushima School of Medicine, Tokushima

Kuniaki Fukuda, MD

Section of Child Neurology, Kagawa Children's Hospital, Zentuji, Japan

Shoichi Endo, MD

Section of Child Neurology, Kagawa Children's Hospital, Zentuji, Japan

Masahito Miyazaki, MD

Department of Pediatrics, University of Tokushima School of Medicine, Tokushima

Kazuyoshi Murakawa, MD

Department of Pediatrics, University of Tokushima School of Medicine, Tokushima

Masanobu Tayama, MD

Department of Pediatrics, University of Tokushima School of Medicine, Tokushima

Yasuhiro Kuroda, MD

Department of Pediatrics, University of Tokushima School of Medicine, Tokushima

Circadian rhythm and sleep were studied in three hydranencephalic infants who were diagnosed on the basis of computed tomographic and/or magnetic resonance imaging scans and electrophysiologic findings. In all three cases, although the active sleep cycle was preserved, quiet sleep decreased and indeterminate sleep increased. The sleep-circadian rhythm was disturbed in all three cases. The hormone secretion rhythm was studied in two cases (cases 1 and 3). In both cases, cortisol secretion showed two or three peaks during the day. In one case (case 3), growth hormone secretion did not show sleep enhancement. Prolactin secretion showed an increase during sleep in both cases. The circadian rhythm of body temperature appeared at 6 months of age and disappeared after 1 year of age in case 1. Case 2 did not show a circadian rhythm of body temperature, but case 3 did at 2 years 6 months of age. However, it was thought that the circadian rhythm of body temperature in case 3 was a false one due to severe opisthotonus. Thus, it is suggested that the development of the circadian rhythm may require the rostral brain structure more than the midbrain and that there may be multiple oscillators in humans (J Child Neurol 1992;7:188-194).

Journal of Child Neurology, Vol. 7, No. 2, 188-194 (1992)
DOI: 10.1177/088307389200700209


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?