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Journal of Child Neurology
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Topical Review Article: Medulloblastoma: II. A Pathobiologic Overview

Frank H. Tomlinson, MBBS, FRACS, PhD

Department of Neurosurgery, Mayo Clinic, Rochester, MN

Bernd W. Scheithauer, MD

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

Robert B. Jenkins, MD, PhD

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

The pathobiology of medulloblastoma is reviewed in light of emerging data regarding its immunocytochemical and cytobiologic, as well as molecular biologic, characteristics. The nature of the lesion, particularly its nosologic relation to primitive neuroectodermal tumor, is discussed, as is its place in the World Health Organization classification of tumors of the central nervous system. (J Child Neurol 1992;7:240-252).

Journal of Child Neurology, Vol. 7, No. 3, 240-252 (1992)
DOI: 10.1177/088307389200700302
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