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Journal of Child Neurology
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A Child With Valproic Acid-Associated Carnitine Deficiency and Carnitine-Responsive Cardiac Dysfunction

Susan L. Bratton, MD

Department of Anesthesiology

Alexander L. Garden, MD

Auckland Hospital, Auckland, New Zealand

Timothy P. Bohan, MD, PhD

Departments of Neurology, Pediatrics, and Pharmacology, University of Texas Medical School, Houston, TX

James W. French, MD

Department of Pediatrics, University of Washington, Seattle, WA

William R. Clarke, MSc, MD

Department of Anesthesiology, Department of Pediatrics, University of Washington, Seattle, WA

Valproic acid enhances renal losses of carnitine esters and leads to decreased plasma free carnitine concentrations in many patients receiving valproic acid therapy. However, decreased serum carnitine levels are of unclear pathologic significance, and most children manifest no symptoms of carnitine deficiency. We report a child with valproic acid-associated carnitine deficiency who had severe cardiac dysfunction develop that resolved with carnitine replacement therapy. (J Child Neurol 1992;7:413-416).

Journal of Child Neurology, Vol. 7, No. 4, 413-416 (1992)
DOI: 10.1177/088307389200700416
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This article has been cited by other articles:


Home page
 J Child NeurolHome page
R. Pons and D. C. De Vivo
Primary and Secondary Carnitine Deficiency Syndromes
J Child Neurol, November 1, 1995; 10(2_suppl): 2S8 - 2S24.
[Abstract] [PDF]