This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Bodensteiner, J. Articles by Cowan, L. Search for Related Content PubMed PubMed Citation Articles by Bodensteiner, J. Articles by Cowan, L. Social Bookmarking                         What's this?

Hypoplasia of the Corpus Callosum: A Study of 445 Consecutive MRI Scans

Departments of Neurology and Pediatrics West Virginia University, Morgantown, WV

G.B. Schaefer, MD

Department of Pediatrics Meyer Rehabilitation Institute, University of Nebraska, Omaha, NE

Lisa Breeding

Departments of Neurology and Pediatrics West Virginia University, Morgantown, WV

Linda Cowan, PhD

Department of Biostatistics and Epidemiology University of Oklahoma, Oklahoma City, OK

The size of the corpus callosum was assessed visually and by computer-assisted image analysis in a series of 445 consecutive magnetic resonance imaging (MRI) scans in children under 17 years of age. Fifty individuals were subjectively identified with small corpora callosa on visual inspection of the MRI scans. Seven patients had true hypoplasia of the corpus callosum after comparing the computer-measured relative size of the structure to previously established normal values. Five additional patients had complete agenesis, and two had partial agenesis of the corpus callosum. The cognitive functional levels of the seven patients with callosal hypoplasia and a control group of 63 randomly selected individuals from the remainder of the group were ascertained by record review. Seventy-one percent of the patients with hypoplasia of the corpus callosum and 29% of the control group had impaired function. The P value determined by Fisher's exact test was P = .061, suggesting that further study with greater numbers may be warranted. The prevalence of mental retardation in this condition, and the fact that hypoplasia is as common as complete and partial agenesis of the corpus callosum combined, suggest that hypoplasia of the corpus callosum is a marker of cerebral dysgenesis that should be looked for in the appropriate clinical setting. (J Child Neurol 1994;9:47-49).

Journal of Child Neurology, Vol. 9, No. 1, 47-49 (1994)
DOI: 10.1177/088307389400900111


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. A. Brumback The Silver Jubilee: Journal of Child Neurology Turns 25 J Child Neurol, January 1, 2010; 25(1): 4 - 31. [PDF]

				J. B. Bodensteiner and S. D. Johnsen Magnetic Resonance Imaging (MRI) Findings in Children Surviving Extremely Premature Delivery and Extremely Low Birthweight With Cerebral Palsy J Child Neurol, September 1, 2006; 21(9): 743 - 747. [Abstract] [PDF]

				Y.-t. Ng, C. M. McCarthy, T. J. Tarby, and J. B. Bodensteiner Agenesis of the Corpus Callosum Is Associated With Feeding Difficulties J Child Neurol, June 1, 2004; 19(6): 443 - 446. [Abstract] [PDF]

				M. I. Shevell Clinical and Diagnostic Profile of Agenesis of the Corpus Callosum J Child Neurol, December 1, 2002; 17(12): 895 - 899. [Abstract] [PDF]

				O. Gabrielli, S. Bruni, G. V. Coppa, I. Carloni, G. Polonara, L. Regnicolo, S. Salvolini, and U. Salvolini White-Matter Alterations and Callosal Abnormalities in Syndromic Patients With Mental Retardation J Child Neurol, March 1, 2002; 17(3): 164 - 168. [Abstract] [PDF]

				P. Nopoulos, S. Berg, F. X. Castellenos, A. Delgado, N. C. Andreasen, and J. L. Rapoport Developmental Brain Anomalies in Children With Attention-Deficit Hyperactivity Disorder J Child Neurol, February 1, 2000; 15(2): 102 - 108. [Abstract] [PDF]

				M Taylor and A S David Agenesis of the corpus callosum: a United Kingdom series of 56 cases J. Neurol. Neurosurg. Psychiatry, January 1, 1998; 64(1): 131 - 134. [Abstract] [Full Text]

				C. B. Brill, J. Gutierrez, and M. M. Mishkin Chiari I Malformation: Association With Seizures and Developmental Disabilities J Child Neurol, February 1, 1997; 12(2): 101 - 106. [Abstract] [PDF]