This Article Full Text (PDF) References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Kosofsky, B. E. Articles by Evrard, P. Search for Related Content PubMed PubMed Citation Articles by Kosofsky, B. E. Articles by Evrard, P. Social Bookmarking                         What's this?

Transplacental Cocaine Exposure: A Mouse Model Demonstrating Neuroanatomic and Behavioral Abnormalities

Laboratory of Molecular and Developmental Neuroscience Massachusetts General Hospital, Department of Neurology Massachusetts General Hospital and Harvard Medical School, Boston, MA

Aaron S. Wilkins, BS

Laboratory of Molecular and Developmental Neuroscience Massachusetts General Hospital

Pierre Gressens, MD

Laboratoire de Neurologie du Développement University of Louvain Medical School, Brussels, Belgium

Philippe Evrard, MD

Laboratoire de Neurologie du Développement University of Louvain Medical School, Brussels, Belgium

Between 10% and 15% of infants born in urban America today have been exposed to cocaine in utero. Clinical studies have suggested that impairment of brain growth is the single best marker of significant prenatal cocaine exposure, and postnatal developmental compromise seen in a subset of affected children as a consequence of that exposure. We have developed an animal model, in mice, of prenatal cocaine exposure that has allowed us to dissociate the direct effects of cocaine in altering fetal development from the indirect effects associated with cocaine-induced malnutrition. We find that transplacental cocaine exposure independently impairs fetal brain and body growth and results in behavioral deficits and permanent alterations in neocortical cytoarchitecture in exposed offspring. (J Child Neurol 1994;9:234-241).

Journal of Child Neurology, Vol. 9, No. 3, 234-241 (1994)
DOI: 10.1177/088307389400900303


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				J. E. Crandall, H. E. Hackett, S. A. Tobet, B. E. Kosofsky, and P. G. Bhide Cocaine Exposure Decreases GABA Neuron Migration from the Ganglionic Eminence to the Cerebral Cortex in Embryonic Mice Cereb Cortex, June 1, 2004; 14(6): 665 - 675. [Abstract] [Full Text] [PDF]

				N. Ohtani, T. Goto, C. Waeber, and P. G. Bhide Dopamine Modulates Cell Cycle in the Lateral Ganglionic Eminence J. Neurosci., April 1, 2003; 23(7): 2840 - 2850. [Abstract] [Full Text] [PDF]

				M. S. Lidow and Z.-M. Song Effect of Cocaine on Cell Proliferation in the Cerebral Wall of Monkey Fetuses Cereb Cortex, June 1, 2001; 11(6): 545 - 551. [Abstract] [Full Text] [PDF]

				L. B. Jones, G. D. Stanwood, B. S. Reinoso, R. A. Washington, H.-Y. Wang, E. Friedman, and P. Levitt In Utero Cocaine-Induced Dysfunction of Dopamine D1 Receptor Signaling And Abnormal Differentiation of Cerebral Cortical Neurons J. Neurosci., June 15, 2000; 20(12): 4606 - 4614. [Abstract] [Full Text] [PDF]

				S. M. Potter, P. R. Zelazo, D. M. Stack, and A. N. Papageorgiou Adverse Effects of Fetal Cocaine Exposure on Neonatal Auditory Information Processing Pediatrics, March 1, 2000; 105(3): 40e - 40. [Abstract] [Full Text]

				S. C. Baraban and P. A. Schwartzkroin Effects of Prenatal Cocaine Exposure on the Developing Hippocampus: Intrinsic and Synaptic Physiology J Neurophysiol, January 1, 1997; 77(1): 126 - 136. [Abstract] [Full Text] [PDF]