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Efficacy of Thyrotropin-Releasing Hormone in the Treatment of Spinal Muscular Atrophy

Department of Pediatrics Kyoto Prefectural University of Medicine

Yuri Miyanomae, MD

Kyoto City Child Welfare Center Kyoto, Japan

Hiroshi Komatsu, MD

Department of Pediatrics Kyoto Prefectural University of Medicine

Yoshikazu Oomizono, MD

Department of Pediatrics Kyoto Prefectural University of Medicine

Akira Nishimura, MD

Department of Pediatrics Kyoto Prefectural University of Medicine

Sozo Okano, MD

Department of Pediatrics Kyoto Prefectural University of Medicine

Tetuo Nishiki, MD

Department of Pediatrics Kyoto Prefectural University of Medicine

Tadashi Sawada, MD

Department of Pediatrics Kyoto Prefectural University of Medicine

Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy. (J Child Neurol 1994;9:287-289).

Journal of Child Neurology, Vol. 9, No. 3, 287-289 (1994)
DOI: 10.1177/088307389400900313


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