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Journal of Child Neurology
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*Brain Cancer
*Childhood Brain Tumors
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Initial Management of Childhood Brain Tumors: Neurosurgical Considerations

Farideh Nejat, MD, MPH

Department of Neurosurgery, Children's Hospital Medical Center, Medical Sciences/University of Tehran, Tehran, Iran

Mostafa El Khashab, MD, PhD

Department of Neurosurgery, Hackensack University Medical Center, Hackensack, New Jersey

James T. Rutka, MD, PhD, FRCSC, FACS

Division of Neurosurgery, The Hospital for Sick Children, The University of Toronto, Toronto, Canada, james.rutka{at}sickkids.ca

Intracranial tumors are the most common solid tumors in children. The infratentorial compartment will be the primary site for 60% to 70% of these tumors, including astrocytomas, medulloblastomas, and ependymomas. Several technological advancements have increased our knowledge of the cell biology of pediatric brain tumors, facilitated earlier diagnosis, and improved neurosurgical resections while minimizing neurological deficits. These in turn have not only improved the survival of children with brain tumors but also their quality of life. Current management strategies in most cases rely on surgery coupled with adjuvant therapies, including radiation therapy and chemotherapy. The vulnerability of the immature brain to adjuvant therapies creates many challenges for the treating physician. We review current diagnostic and therapeutic approaches and outcome for children harboring the most common pediatric brain tumors: astrocytomas (low-grade and high-grade glioma), ependymoma, medulloblastoma, and craniopharyngioma. The emphasis will be on the neurosurgical management of children with these tumors.

Key Words: craniopharyngioma • ependymoma • glioma • medulloblastoma • pediatric brain tumors • neurosurgery

References

Journal of Child Neurology, Vol. 23, No. 10, 1136-1148 (2008)
DOI: 10.1177/0883073808321768
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[Abstract] [Full Text] [PDF]

This Article
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Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Nejat, F.
Right arrow Articles by Rutka, J. T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nejat, F.
Right arrow Articles by Rutka, J. T.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Brain Cancer
*Childhood Brain Tumors
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?