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Journal of Child Neurology
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Hyaluronan Regulates Ceruloplasmin Production By Gliomas and Their Treatment-Resistant Multipotent Progenitors

Sandra L. Tye, MS

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, South Carolina

Anne G. Gilg, PhD

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, South Carolina

Lauren B. Tolliver, MS

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, South Carolina

William G. Wheeler, BS

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, South Carolina

Bryan P. Toole, PhD

Department of Cell Biology and Anatomy Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, South Carolina

Bernard L. Maria, MD MBA

Department of Pediatrics, Charles P. Darby Children's Research Institute, College of Medicine, Medical University of South Carolina, South Carolina, mariabl{at}musc.edu

Ceruloplasmin (glycosylphosphatidylinositol-linked ferroxidase associated with normal astrocytes) can also be secreted by glioma cells, where its function is unknown. Ceruloplasmin is not only present in glioma cells and in human glioma specimens but also is enriched in highly malignant glioma stem-like cells. Hyaluronan is a large extracellular glycosaminoglycan that enhances malignant glioma behaviors by interacting with CD44 receptors and by downstream activation of signaling proteins and transporters associated with malignancy. We examined the relationship between hyaluronan and ceruloplasmin expression in glioma stem-like cells. Antagonism of hyaluronan interactions with short-fragment hyaluronan oligomers decreased ceruloplasmin expression in parental and stem-like glioma cells in vivo and in cell culture, implying that hyaluronan regulates ceruloplasmin expression. Further gain and loss-of-function studies are needed to fully define the relationship between hyaluronan and ceruloplasmin, and ceruloplasmin's effect on malignant behaviors.

Key Words: ceruloplasmin • hyaluronan • glioma • stem-like cells • glycosaminoglycan

References

Journal of Child Neurology, Vol. 23, No. 10, 1221-1230 (2008)
DOI: 10.1177/0883073808321066
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This Article
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PubMed
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Right arrow Articles by Maria, B. L.
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