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Journal of Child Neurology
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Reviews

Attention-Deficit Disorders and Epilepsy in Childhood: Incidence, Causative Relations and Treatment Possibilities

Rami Kaufmann, MD

Department of Child Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel

Hadassa Goldberg-Stern, MD

Epilepsy Clinic, Schneider Children's Medical Center of Israel, Petach Tikva, Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel

Avinoam Shuper, MD

Department of Child Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, Sackler School of Medicine Tel Aviv University, Tel Aviv, Israel, AVINOAMS{at}clalit.org.il

At least 20% of children with epilepsy have clinical attention-deficit hyperactivity disorder (ADHD) compared to 3% to 7% of the general pediatric population. Several mechanisms may account for the high prevalence, such as a common genetic propensity, noradrenergic system dysregulation, subclinical epileptiform discharges, or even seizures, antiepileptic drug effects, and psychosocial factors. At the same time, children with attention-deficit hyperactivity disorder have a higher than normal rate of electroencephalography abnormalities (5.6-30.1% vs. 3.5%). Methylphenidate treatment is equally efficient in children with isolated attention-deficit hyperactivity disorder and in children with attention-deficit hyperactivity disorder and epilepsy (70%-77%). Electroencephalography screening in patients with attention-deficit hyperactivity disorder in the absence of other clinical indications or before starting methylphenidate treatment is not currently indicated. Methylphenidate is considered safe for use in children who are seizure-free. However, the few reports of seizure aggravation in methylphenidate-treated children with uncontrolled epilepsy have raised concern.

Key Words: attention-deficit hyperactivity disorder (ADHD) • epilepsy • methylphenidate

References

  • Rappley MD Attention deficit hyperactivity disorder. N Engl J Med. 2005;352:165-173.[Free Full Text]
  • Polanczyk G., de Lima MS, Horta BL, et al. The worldwide prevalence of ADHD: a systemic review and metaregression analysis. Am J Psychiatry. 2007;164:942-948.[Abstract/Free Full Text]
  • Seidman LJ, Valera EM, Makris N. Structural brain imaging of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57: 1263-1272.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Castellanos FX, Lee PP, Sharp W., et al. Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit/hyperactivity disorder. JAMA. 2002;288: 1740-1748.[Abstract/Free Full Text]
  • Bush G., Valera EM, Seidman LJ Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions. Biol Psychiatry. 2005;57:1273-1284.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Alexander GE, DeLong MR, Strick PL Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci. 1986;9:357-381.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Zametkin AJ, Rapoport JL Noradrenergic hypothesis of attention deficit disorder with hyperactivity: a critical review. In: Meltzer HY, ed. Psychopharmacology: The Third Generation of Progress. New York: Raven Press; 1987:837-842.
  • Pliszka SR Comorbidity of attention-deficit/hyperactivity disorder with psychiatric disorder: an overview. J Clin Psychiatry. 1998;59:50-58.
  • Berquin PC, Giedd JN, Jacobsen LK, et al. Cerebellum in attention-deficit hyperactivity disorder: a morphometric MRI study. Neurology. 1998;50:1087-1093.[Abstract/Free Full Text]
  • Bauman RJ Classification and population studies of epilepsy. In: Anderson VA, ed. Genetic Basis of the Epilepsies. New York: Raven Press; 1982:11-20.
  • Goodbridge DMG, Shorvon SD Epileptic seizures in a population of 6000. I. Demography, diagnosis and classification and role of the hospital services. Br Med J. 1983;287:641-645.[Abstract/Free Full Text]
  • Gross-Tsur V., Manor O., van der Meere J., et al. Epilepsy and attention deficit hyperactivity disorder: is methylphenidate safe and effective? J Pediatr. 1997;130:670-674.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Dunn DW, Austin JK, Harezlak J., Ambrosius WT ADHD and epilepsy in childhood. Dev Med Child Neurol. 2003;45:50-54.[Web of Science][Medline] [Order article via Infotrieve]
  • Richer LP, Shevell MI, Rosenblatt BR Epileptiform abnormalities in children with attention-deficit-hyperactivity disorder. Pediatr Neurol. 2002;26:125-129.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hughes JR, Deleo AJ, Melyn MA The electroencephalogram in attention deficit-hyperactivity disorder: emphasis on epileptiform discharges. Epilepsy Behav. 2000;1:271-277.[CrossRef][Medline] [Order article via Infotrieve]
  • Holtmann M., Becker K., Kentner-Figura B., Schmidt MH Increased frequency of rolandic spikes in ADHD children. Epilepsia. 2004;44:1241-1244.[CrossRef][Web of Science]
  • Becker K., Sinzig JK, Holtmann M. Attention deficits and subclinical epileptiform discharges: are EEG diagnostics in ADHD, optional or essential? Dev Med Child Neurol. 2004;46: 431-432.[Web of Science][Medline] [Order article via Infotrieve]
  • Tan M., Appleton R. Attention deficit and hyperactivity disorder, methylphenidate and epilepsy. Arch Dis Child. 2005;90:57-59.[Abstract/Free Full Text]
  • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: APA Press; 1994.
  • Weinberg WA, Harper CR, Schraufnagel CD, Brumback RA Attention deficit and hyperactivity disorder: a disease or a symptom complex? J Pediatr. 1997;130:665-669.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hesdorffer DC, Ludvigsson P., Olafsson E., et al. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry. 2004;61:731-736.[Abstract/Free Full Text]
  • Weinshenker D., Szot P. The role of catecholamines in seizure susceptibility. New results using genetically engineered mice. Pharmacol Ther. 2002;94:213-233.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Dailey JW, Mishra PK, Ko KH, et al. Noradrenergic abnormalities in the central nervous system of seizure-naïve genetically epilepsy-prone rats. Epilepsia. 1991;32:168-173.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Anderson GM, Dover MA, Yang BP, et al. Adrenomedullary function during cognitive testing in attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2000;39: 635-643.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Hermann B., Jones J., Dabbs K., et al. The frequency, complication and aetiology of ADHD in new onset paediatric epilepsy. Brain. 2007;12:3135-3148.
  • Austin JK, Harezlak J., Dunn DW, et al. Behavior problems in children before first recognized seizures. Pediatrics. 2001;107: 115-122.[Abstract/Free Full Text]
  • Marston D., Besag F., Binnie CD, Fowler M. Effects of transitory cognitive impairment on psychosocial functioning of children with epilepsy: a therapeutic trial. Dev Med Child Neurol. 1993;35:574-581.[Web of Science][Medline] [Order article via Infotrieve]
  • Murphy P., Burnham WM The ketogenic diet causes a reversible decrease in activity level in Long-Evans rats. Exp Neurol. 2006;201:84-89.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Lerman P., Lerman-Sagie T., Kivity S. Effect of early corticosteroid therapy for Landau Kleffner syndrome. Dev Med Child Neurol. 1991;33:257-260.[Web of Science][Medline] [Order article via Infotrieve]
  • Williams J., Bates S., Griebel ML, et al. Does short-term antiepileptic drug treatment in children result in cognitive or behavioral changes? Epilepsia. 1998;39:1064-1069.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Aldenkamp AP, Alpherts WCJ, Blennow G., et al. Withdrawal of antiepileptic medication in children. Effects on cognitive function. The Multicenter Holmfrid Study. Neurology. 1993;43:41-50.[Abstract/Free Full Text]
  • Bourgeois BFD Antiepileptic drugs, learning and behavior in childhood epilepsy. Epilepsia. 1998;39:913-921.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Martin R., Kuzniecky R., Ho S., et al. Cognitive effects of topiramate, gabapentin, and lamotrigine in healthy young adults. Neurology. 2000;52:321-327.[Web of Science]
  • Barkley RA Attention Deficit Hyperactivity Disorder. 2nd ed. New York: Guilford Press; 1998:175-176.
  • Oostrom KJ, Schouten A., Kruitwagen CLJ, et al. Attention deficits are not characteristic of schoolchildren with newly diagnosed idiopathic or cryptogenic epilepsy. Epilepsia. 2002;43: 301-310.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Szatmari P., Offord DR, Boyle MH The Ontario child health study: prevalence of attention deficit disorder with hyperactivity. J Child Psychol Psychiatry. 1989;30:219-230.[Web of Science][Medline] [Order article via Infotrieve]
  • Castellanos FX Neuroimaging studies of ADHD. In: Solanto MV, Arnsten AFT, Castellanos FX, eds. Stimulant Drugs and ADHD. New York: Oxford University Press; 2001:243-258.
  • Stein MA, Blondis TA Methylphenidate dosing: twice daily versus three times daily. Pediatrics. 1996;98:748-756.[Abstract/Free Full Text]
  • Feldman H., Crumrine P., Handen BL, Alvin R., Teodori J. Methylphenidate in children with seizures and attention deficit disorder. Am J Dis Child. 1989;143:1081-1086.[Abstract/Free Full Text]
  • Gucuyener K., Erdemoglu K., Senol S., et al. Use of methylphenidate for attention-deficit hyperactivity disorder in patients with epilepsy or electroencephalographic abnormalities. J Child Neurol. 2003;18:109-112.[Abstract/Free Full Text]
  • Clarke AR, Barry RJ, Bond D., et al. Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder. Psychopharmacology. 2002;164:277-278.[CrossRef][Medline] [Order article via Infotrieve]
  • Hemmer SA, Pasternak JF, Zecker SG, Trommer BL Stimulant therapy and seizure risk in children with ADHD. Pediatr Neurol. 2001;24:99-102.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wroblewski BA, Leary JM, Phelan AM, et al. Methylphenidate and seizure frequency in brain-injured patients with seizure disorders. J Clin Psychiatry. 1992;53:86-89.[Web of Science][Medline] [Order article via Infotrieve]
  • McBride MC, Wang DD, Torres CF Methylphenidate in therapeutic doses does not lower seizure threshold. Ann Neurol. 1986;20:428.
  • Gonzales-Heydrich J., Hsin O., Hickory M., et al. Comparisons of response to stimulant preparations in pediatric epilepsy. Meeting of the American Academy of Child and Adolescent Psychiatry, 2004, Washington, DC.
  • Baptista-Neto L., Dodds A., Rao S., et al. An expert opinion on methylphenidate treatment for attention deficit hyperactivity disorder in pediatric patients with epilepsy. Expert Opin Investig Drugs. 2008;17:77-84.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Torres AR, Whitney J., Gonzalez-Heydrich J. Attention-deficit/ hyperactivity disorder in pediatric patients with epilepsy: review of pharmacological treatment. Epilepsy Behav. 2008;12: 217-233.[CrossRef][Web of Science][Medline] [Order article via Infotrieve]
  • Wernicke JF, Holdrige KC, Jin L., et al. Seizure risk in patients with attention deficit hyperactivity disorder treated with atomoxetine. Dev Med Child Neurol. 2007;49:498-502.[Web of Science][Medline] [Order article via Infotrieve]

Journal of Child Neurology, Vol. 24, No. 6, 727-733 (2009)
DOI: 10.1177/0883073808330165
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
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Right arrow Email this article to a friend
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Citing Articles
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kaufmann, R.
Right arrow Articles by Shuper, A.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kaufmann, R.
Right arrow Articles by Shuper, A.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Attention Deficit Hyperactivity Disorder
*Epilepsy
Hazardous Substances DB
*METHYLPHENIDATE
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