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Role of Continuous Positive Airway Pressure Therapy on the Pathogenesis of Sleep-Related Frontal Lobe Epilepsy in a Child With Obstructive Sleep Apnea Syndrome
Silvia Miano, MD,
Andrea Pelliccia, MD,
Melania Evangelisti, MD,
Jacopo Pagani, MD,
and
Maria Pia Villa, MD*
* To whom correspondence should be addressed. E-mail: mariapia.villa{at}uniroma1.it.
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Abstract |
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We describe an obese child with severe obstructive sleep apnea syndrome in whom nocturnal frontal lobe seizures developed within a week after therapy was started with continuous positive airway pressure. The video polysomnographic study after the onset of nocturnal episodes showed 3 seizures: 2 starting from slow-wave sleep when he was sleeping with continuous positive airway pressure, and 1 from stage 2 non–rapid eye movement sleep when he was sleeping without continuous positive airway pressure. Cyclic alternating pattern analysis during the video polysomnography recorded after the onset of nocturnal seizures disclosed a high cyclic alternating pattern rate during slow-wave sleep, and the recording obtained after antiepileptic therapy began showed a low cyclic pattern analysis rate. In this child, we describe the non–rapid eye movement sleep instability induced by continuous positive airway pressure therapy might have had a role in triggering the nocturnal seizures.
First published on December 13, 2007, doi:10.1177/0883073807308690
Journal of Child Neurology 2008;23:124.
A more recent version of this article appeared on January 1, 2008
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