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Journal of Child Neurology
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0883073807308714v1
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Article

Mycoplasma pneumoniae Infection and Obsessive-Compulsive Disease: A Case Report

Tugba Erener Ercan, MD*, Gokmen Ercan, MD, Burcu Severge, MD, Muhsin Arpaozu, MD, and Gulten Karasu, MD

Maltepe University Medical Faculty, Department of Pediatrics, Maltepe, Istanbul, Turkey

* To whom correspondence should be addressed. E-mail: tugbaerener{at}yahoo.com.


  Abstract
It has been demonstrated that obsessive-compulsive disease and/or tic syndromes in children may be triggered by an antecedent infection especially with group A beta-hemolytic streptococci, and this subgroup of children has been designated by the acronym PANDAS (pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections). Other infectious agents such as viruses and bacteria have also been reported to be associated with the acute onset or dramatic exacerbation of obsessive-compulsive disease or Tourette syndrome, and another acronym, PITAND (pediatric infection-triggered autoimmune neuropsychiatric disorder) has appeared in the literature. The involvement of other infectious agents such as Mycoplasma pneumoniae has been described in single case reports. We describe a case of a 5.5-year-old boy who suddenly developed obsessive-compulsive disease symptoms during a M. pneumoniae pneumonia. After treatment with oral clarithromycin, all his obsessive-compulsive disease symptoms disappeared. To our knowledge, this is the first report that shows the association between Mycoplasma pneumoniae infection and obsessive-com-pulsive disease.

First published on December 13, 2007, doi:10.1177/0883073807308714

Journal of Child Neurology 2008;23:338.

A more recent version of this article appeared on March 1, 2008

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