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Journal of Child Neurology
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0883073807309232v1
23/4/421    most recent
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Article

Effects of Postnatal Dexamethasone Exposure on the Developmental Outcome of Premature Infants

Howard Needelman, MD*, Martha Evans, MSN, APRN, Holly Roberts, PhD, Matthew Sweney, MD, and J. B. Bodensteiner, MD

* To whom correspondence should be addressed. E-mail: hneedelm{at}unmc.edu.


  Abstract
Extremely low birth weight premature infants are at risk for poor neurodevelopmental outcome. Postnatal dexamethasone has often been used in premature infants to prevent or treat bronchopulmonary dysplasia, and this drug is thought by some to affect neurodevelopmental outcome. We retrospectively examined the effect of this steroid on early neurodevelopment. Dexamethasone exposure was associated with an adverse outcome and was a stronger predictor of outcome than other accepted risk factors. If used, dexamethasone should be used in these high-risk infants for as short a period as possible.

First published on December 13, 2007, doi:10.1177/0883073807309232

Journal of Child Neurology 2008;23:421.

A more recent version of this article appeared on April 1, 2008

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 J Child NeurolHome page
J. J. Volpe
Cerebellum of the Premature Infant: Rapidly Developing, Vulnerable, Clinically Important
J Child Neurol, September 1, 2009; 24(9): 1085 - 1104.
[Abstract] [PDF]