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Neuropsychiatric Disorders in Males With Duchenne Muscular Dystrophy: Frequency Rate of Attention-Deficit Hyperactivity Disorders (ADHD), Autism Spectrum Disorder, and Obsessive–Compulsive Disorder

¹ Kempenhaeghe Epilepsy Centre, Department of Behavioral Sciences, Heeze, and Maastricht University Hospital, Department of Neurology, The Netherlands
² Maastricht University Hospital, Department of Neurology, The Netherlands

^* To whom correspondence should be addressed. E-mail: hendriksenJ{at}kempenhaeghe.nl.

	Abstract

Using a questionnaire-based study, we assessed the parent-reported prevalence of attention-deficit hyperactivity disorders (ADHDs), autism spectrum disorders, and obsessive–compulsive disorders in a group of 351 males with Duchenne muscular dystrophy. Of the 351 males with Duchenne muscular dystrophy, 11.7% were reported to have a comorbid diagnosis of ADHD, 3.1% had autism spectrum disorder, and 4.8% had obsessive–compulsive disorder. It can be concluded that the incidence of these neuropsychiatric disorders is higher in Duchenne males than in the normal population. This finding, together with recent reports on the higher prevalence of cognitive and learning problems in Duchenne, supports the view that Duchenne muscular dystrophy is not only a muscular disorder but also a disorder affecting the brain. It is important for clinical practice to take in account this heightened association. More research is needed to examine this association and its consequences.

First published on March 19, 2008, doi:10.1177/0883073807309775

Journal of Child Neurology 2008;23:477.

A more recent version of this article appeared on May 1, 2008


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