Journal of Child Neurology

 

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0883073807309789v1
23/5/526    most recent
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First published on December 3, 2007, doi:10.1177/0883073807309789

Journal of Child Neurology 2008;23:526.

A more recent version of this article appeared on May 1, 2008

Article

Prevalence and Outcome of Congenital Heart Disease in Patients With Neural Tube Defect

Gülendam Koçak, MD*, Çagatay Önal, MD, Ayhan Koçak, MD, Cemsit Karakurt, MD, Özkan Ates, MD, Süleyman R. Çayli, MD, and Saim Yologlu, PhD

* To whom correspondence should be addressed. E-mail: gul_endam{at}yahoo.com.


  Abstract
A prospective clinical study was designed to establish the risk factors, the prevalence, and the progress of congenital heart defects in children with neural tube defects. Study included 90 children with a mean age of 13.5 ± 30.4 months. There were 53 (59%) patients with spina bifida occulta and 37 (41%) patients with spina bifida aperta. The overall prevalence of congenital heart disease was 27.8% (40.5% in spina bifida aperta and 18.9% in spina bifida occulta; P = .024). There was no statistically significant difference for maternal age, usage of periconceptional folate, and maternal diabetes between the patient and control groups. The authors conclude that congenital heart defects are more common than reported in neural tube defects, and screening echocardiograms are warranted. This should be kept in mind especially in patients requiring minor or major surgical procedures. Furthermore, routine obstetric examination and therefore the use of periconceptional folic acid during pregnancy is still lacking in our country.


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